Serum checkpoint molecules in patients with IgG4-related disease (IgG4-RD)

Abstract Background Immunoglobulin G4-related disease (IgG4-RD) is characterized by increased serum IgG4 concentration and infiltration of + plasma cells in the affected organs. The present study aimed to characterize levels coinhibitory checkpoint molecule, T cell immunoglobulin mucin-containing-molecule-3 (TIM-3), its ligand, galectin-9 (Gal-9), among IgG4-related patients with IgG4-RD various organ involvements. Methods Serum samples were collected from untreated 59 IgG4-RD, 13 rheumatoid arthritis, 37 healthy controls (HCs). HCs lacked chronic medical diseases or conditions did not take prescription medications over-the-counter within 7 days. Patients (n = 57) subdivided into those visceral involvement 38) without 21). Gal-9 soluble TIM-3 (sTIM-3) determined using enzyme-linked immunosorbent assay (ELISA). results compared clinical phenotypes IgG4-RD. Results In sTIM-3 significantly higher than RA as well controls. There significant correlations between IgG, BAFF, sIL-2R. However, there was no correlation concentrations. a subset involvements difference involvements, although both elevated patients, these molecules remained unchanged after steroid therapy. Conclusion Furthermore, These could be potentially useful biomarker for assessing